COVID-19 Autopsies, Oklahoma, USA
Identifieur interne : 000720 ( 2020/Analysis ); précédent : 000719; suivant : 000721COVID-19 Autopsies, Oklahoma, USA
Auteurs : Lisa M. Barton [États-Unis] ; Eric J. Duval [États-Unis] ; Edana Stroberg [États-Unis] ; Subha Ghosh [États-Unis] ; Sanjay Mukhopadhyay [États-Unis]Source :
- American Journal of Clinical Pathology [ 0002-9173 ] ; 2020.
Abstract
To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS
Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs.
A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis.
SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.
Url:
DOI: 10.1093/ajcp/aqaa062
PubMed: 32275742
PubMed Central: 7184436
Affiliations:
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PMC:7184436Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec id="s0100"><title>Objectives</title>
<p>To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS<italic>-</italic>
CoV<italic>-</italic>
2) positive individuals who died in Oklahoma (United States) in March 2020.</p>
</sec>
<sec id="s0101"><title>Methods</title>
<p>Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs.</p>
</sec>
<sec id="s0102"><title>Results</title>
<p>A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis.</p>
</sec>
<sec id="s0103"><title>Conclusions</title>
<p>SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.</p>
</sec>
</div>
</front>
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<tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Barton, Lisa M" sort="Barton, Lisa M" uniqKey="Barton L" first="Lisa M" last="Barton">Lisa M. Barton</name>
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<name sortKey="Duval, Eric J" sort="Duval, Eric J" uniqKey="Duval E" first="Eric J" last="Duval">Eric J. Duval</name>
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